Catalyst projects

Developing the people and ideas that will drive healthcare innovation

Catalyst projects involve Fellows and their international teams of collaborators. They focus on identifying unmet medical needs that can be addressed by new biomedical technologies, and launching projects to develop them.

Catalyst projects are shaped by the MIT linQ Innovation Method. This unique method accelerates and heightens the potential for innovation impact by—

  • Helping teams to identify and precisely define medical needs
  • Compressing development time by engaging diverse lifecycle expertise (such as businesspeople, healthcare professionals, and public leaders as well as academic researchers)
  • Encouraging strategic decisions about actions and resources
  • Enabling project teams to become agents of change

Two phases to accelerate innovation

The full program comprises two phases, with a new cohort recruited annually to begin Phase 1.

Phase 1: Discover new project opportunities (6 months)

With guidance from a diverse team of mentors, a cohort of Fellows work together to and validate unmet needs, generate solution ideas matched to those needs, and outline a plan to develop and deploy their solution.  The deliverable for Phase 1 is a portfolio of project proposals.

Phase 2: Project execution (~1-3 years)

Phase 2 focuses on starting and de-risking projects to bring the innovation opportunity from an idea to implementation and impact.

Phase 2 projects

patient in hospital bed

Prevention of Hospital Acquired Pressure Injuries: A novel EHR Dashboard for all paralyzed veterans receiving care

For hospitalized individuals with spinal cord injuries, there is a risk of developing Hospital-Acquired Pressure Injuries (HAPIs). Currently, relevant data on HAPI risk factors is scattered throughout the health record, making it challenging for clinicians to monitor risk regularly. We propose a centralized platform that consolidates up to date HAPI risk factor data, enabling efficient monitoring and personalized prevention strategies. This system aims to reduce HAPI incidence without increasing clinician workload.
Sleeping, snoring man

Obstructive Sleep Apnea (OSA)

Obstructive sleep apnea (OSA), a common, chronic health condition that is prevalent and underdiagnosed, lead to daytime fatigue and drowsiness and are associated with serious health consequences such as hypertension, heart failure, motor vehicle accidents and premature death. Current treatments are underutilized because they’re cumbersome and uncomfortable. The OSA team is developing a novel, comfortable solution that will make compliance easier and more effective.
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Barrier

Unintended pregnancies and sexually transmitted infections (STIs) are increasing, despite public awareness campaigns. Condom use, shown to be an effective response, is hampered by negative perceptions of decreased pleasure and sexual performance. To increase condom use, the Barrier team focused on behavioral and user experience considerations and is developing a novel condom applicator that facilitates efficient, effective application and penile stimulation during condom placement.
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Hydration

Staying hydrated is critical for everyone, and it gets harder with age. The consequences of poor hydration are severe and surprisingly common, especially among the elderly. The Hydration team is designing a technology to help the elderly and their caregivers track hydration status, helping to prevent problems and intervene swiftly when necessary.
Veteran consulting with mental health professional

Veteran Access to Mental Health

Currently in the VA, Veterans seeking a mental health consultation are often delayed as intake coordinators gather necessary information to make an appropriate appointment. The MH Access project seeks to develop a clinical decision support tool that will more efficiently triage patients and get Veterans seen for mental health as soon as possible.
Pregnant woman using mobile app

Birth Experience

As many as 1 in 3 women report poor experience with childbirth that significantly affects their physical and mental health well-being postpartum. We propose creating a new mobile-based application that can help expectant mothers and families better prepare for labor, respond to unexpected labor situations in real-time, and safely transition to part-partum care.
Happy pregnant African-American woman with her toddler

Maternal Health

The maternal health project is working on improving maternal health outcomes for Black pregnant women in the United States. Our focus is on reducing the morbidity and mortality related to preeclampsia by addressing the unique social factors that contribute to the problem.
Bottles of unused medication

Automatic Inactivation of Unused Opioids

Low participation in drug disposal results in the accumulation of millions of unused opioid pills in the community, putting people at risk of addiction and adverse events. Our project aims to develop a pill bottle that automatically inactivates unused opioids, reducing the amount of unused opioids available for misuse, abuse, and diversion.

African American woman having her blood oxygen measured with a pulse oximeter

In transition to Phase 2

Pulse Oximetry and Skin Pigmentation

Thousands of times a day, doctors and nurses use pulse oximeters to noninvasively measure the percentage of oxygen in the blood and make vital treatment decisions in conditions such as asthma, chronic obstructive pulmonary disease, pneumonia, and now COVID-19. However, pulse oximeters are three times more likely to lead to an incorrect clinical decision in Black patients compared to white patients, possibly due in part to skin pigmentation. We propose a novel research study to determine the relationship between skin pigmentation and pulse oximeter measurements, which, if understood, could improve the use of pulse oximetry on Black patients.
Intravenous medications being administered in a hospital room

Medication Administration

Medication errors are one of the leading causes for patient harm in all hospital settings. Bar code medication administration systems have reduced medication administration errors. However, emergency departments have been slow to adopt these systems due to the emergent nature of the clinical scenarios and the workflow burden that these systems place on nurses. We are proposing a new system which will track and document medication administration events in the ED without impacting nurse workflow.
Person with repetitive stress pain in their left hand

Left Thumb Pain in Gastroenterologists Performing Endoscopy

Left thumb injuries are common in gastroenterologists during endoscopy, often due to excessive thumb activity and force when manipulating colonoscope dials. These physical demands can lead to injuries like de Quervain's tenosynovitis. With rising demand for colonoscopy and its increasing complexity, addressing these occupational injuries is essential. Our solution is an add-on device that automates endoscope dial movements, reducing left thumb strain. This alleviates immediate pain for affected physicians and potentially prevents injuries in the long term.
Sleeping veteran

Digital Imagery Rehearsal Therapy for PTSD Patients

In the United States, 70-90% of PTSD patients report sleep issues, which worsen symptoms, prolong recovery, and raise suicide risk. Clinicians often prescribe in-person therapy or medications, but these options have limitations like side effects and limited availability. Imagery Rehearsal Therapy (IRT) effectively treats PTSD-related nightmares. Our digital solution aims to digitize IRT, building on the success of digital therapeutics in delivering cognitive-based therapy. We anticipate similar effects to in-person IRT, reducing nightmare frequency and improving sleep quality.
Closeup of an ear for acupuncture therapy

In transition to Phase 2

Home Delivery of Battlefield Acupuncture for Pain Treatment

Between 60-80% of veterans with chronic pain who have utilized a procedure called Battlefield Acupuncture (BFA), an ear-only type of acupuncture for pain treatment, experience clinically meaningful reduction in pain immediately. Pain relief wanes gradually and subsequent repeated treatment is required. The main failure is these repeated clinic visits which necessitate frequent travel to clinics, lost productivity away from work, and failure to rapidly treat this chronic pain condition. Our device provides an on demand, at-home pain management treatment via in-ear nerve stimulation utilizing BFA concepts.
Upset young woman

Automated Detection of Thought Disorder

Early intervention for youth at clinical high risk for psychosis (CHR-P) can help delay and mitigate onset of psychotic-spectrum disorders. One of the earliest detectable symptoms in youth at CHR-P is Thought Disorder, which manifests itself in the form of subtle changes in language. While these changes can be detected by clinicians, assessment takes four hours and is often unreliable, which prohibits widespread adoption. We propose fully digital detection and scoring of Thought Disorder, improving prediction specificity without burdening clinicians' time.

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Objective Data to Guide Treatment of Sleep Disturbance in PTSD

Disturbed sleep is a core symptom of PTSD, affecting overall health and quality of life, and hindering successful treatments. Patients and providers addressing PTSD-related sleep issues depend on often unreliable self-assessments, leading to treatment choices that are as much gamble as informed decision. there is a need for objective sleep data to provide a more solid foundation for targeted treatment choices. Sleep data from wearables can inform patient/provider collaboration, guiding treatment decisions and adjustments to improve sleep.
Veteran sleeping in bed

Pressure Injury Prevention through Continuous Microclimate Monitoring in Spinal Injury Patients

Preventing pressure injuries requires more than just reducing pressure; maintaining a "skin-friendly" micro-environment around high-pressure areas is crucial. Factors like temperature and humidity significantly impact injury risk. Our goal: design a home-use bed for spinal cord injury individuals that minimizes pressure and controls the microclimate in high-pressure regions. We propose a microclimate monitoring system to record pressure, temperature, and humidity continuously. This bed concept could reduce home-care pressure injuries without burdening caregivers.

Graduated projects

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Early intervention

Projects that can enable earlier, better responses to disease and injury

Reinventing cytometry by providing a means for high-throughput analysis of a blood sample in a monolayer preparation, thereby enabling the identification of rare cells for cancer and other applications. Licensed by Cytognos

Improving colonoscopy lesion detection to reduce colorectal cancer mortality by providing enhanced visualization of difficult-to-see lesions. Transitioned to become a research program at JHU

Detecting an insufficient nutrient transport in the placenta that may put a fetus at risk and indicate the need for early delivery. Transitioned to become a research program at BCH and MIT

A new technology to detect early signs of Parkinson’s disease via native finger interaction with electronic devices during routine use.  Licensed by startup nQ Medical

A new technology to help primary care physicians to quickly identify potentially malignant skin lesions. Transitioned to startup LuminDx

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Managing health

Projects that can help people achieve and maintain better health

Developing imaging biomarkers that help distinguish bipolar disorder from major depressive disorder.

Improving access to eyeglass prescriptions with a new hand-held autorefractor suitable for field use and enabled by advanced optics and analytics. Licensed to startup PlenOptika

Non-invasive screening for dangerously-low white cell counts to provide a first-line indicator of infection and risk of infection, in particular during cycles of chemotherapy. Licensed to startup Leuko

A new wearable technology to provide positional feedback to scoliosis patients to help them control their spinal alignment and reduce their risk of progression and need for more traumatic therapies. Transitioned to AsanawearTech

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Better care delivery

Projects that can make clinical care safer and more effective

Marker for cardiac risk following suspected pulmonary embolism derived from automated analysis of computed tomography (CT) images. Licensed by imbio

Non-invasive method to detect meningitis in infants, thereby avoiding the need for lumbar puncture. Licensed by startup NBS Newborn.Solutions

Enabling simultaneous imaging of multiple PET radiotracers to improve oncologic, neurologic, and cardiac disease management.

Hardware and software innovations to provide personalized MRI to enable enhanced resolution for earlier detection of multiple sclerosis and safe imaging protocols for patients with implanted electrodes.

Monitoring the efficacy of chemotherapy through imaging markers that target the initial stages in tumor cell death, particularly in cancers like melanoma where tumors develop a resistance to therapy.

Developing novel MRI approaches to measure tissue fibrosis in patients with pancreatic cancer as an indicator of therapeutic efficacy

New frontier in cancer treatment

Leuko Labs: White blood cell monitoring without drawing blood

Launched from Catalyst project Team Leuko, Leuko Labs designed PointCheck, the first device for non-invasive white cell monitoring. PointCheck is fast, portable and simple to use. By removing the need for a blood draw, millions of immunosuppressed patients can now be tested more frequently, moving towards improved quality of life and improved clinical outcomes.
Visit startup Leuko Labs
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New clinical tools

PlenOptika: Improving access to vision care for a billion people

PlenOptika is the startup company that emerged from Catalyst project Team Eye in 2014. Their flagship product, QuickSee, is a clinical-quality handheld autorefractor that will help vision care professionals bring high quality care to anyone in the world. QuickSee has already measured 3 million eyes in at least 25 countries.
Visit startup PlenOptika